منابع مشابه
Liver Parenchymal Cell Injury
Accumulation of calcium in the mitochondria of rat liver parenchymal cells at 16 and 24 hours after poisoning with carbon tetrachloride is associated with an increase in amount of liver inorganic phosphate, the persistence of mitochondrial adenosine triphosphatase activity, and the formation of electron-opaque intramitochondrial masses in cells with increased calcium contents. These masses, whi...
متن کاملMechanisms of neutrophil-induced parenchymal cell injury.
Neutrophils are involved in organ damage induced by an excessive acute inflammatory response after ischemia-reperfusion, trauma, and sepsis. In addition to causing vascular injury, neutrophils can transmigrate and attack parenchymal cells. This review summarizes recent advances in our understanding of neutrophil-induced parenchymal cell injury using the liver as an example. Reviewed are the mec...
متن کاملLIVER PARENCHYMAL CELL INJURY VIII. Lesions of Membranous Cellular Components following Iodoform
Iodoform, a relatively water-insoluble yellow solid, chemically reactive in free-radical reactions, produces early hepatocellular injury qualitatively similar to that of carbon tetrachloride . 2 hr after administration of radioactively labeled iodoform, nonvolatile 11C is preferentially recovered in microsomal lipid and protein . By 30 min microsomal properties are profoundly affected : oxidati...
متن کاملAnticoagulants prevent monocrotaline-induced hepatic parenchymal cell injury but not endothelial cell injury in the rat.
Monocrotaline (MCT) is a pyrrolizidine alkaloid plant toxin that produces hepatotoxicity in humans and animals. Human exposure to MCT occurs through consumption of contaminated grains and herbal medicines. Administration of MCT to rats stimulates activation of the coagulation system and fibrin deposition in the liver. Fibrin deposition occurs simultaneously with endothelial cell damage and prio...
متن کاملRat Liver Parenchymal Cell Function during Azo Dye Carcinogenesis.
(I†• tagged) rose bengal uptake-excre tion test for liver function, as described by Taplin et al. (21), has proven to be a valuable test for a quantitative measure of liver function. In rats, I†• rose bengal uptake and excretion are definitively related to parenchymal cell function (21). Mendeloff (10) showed by fluorescence that injected rose bengal is localized only in parenchymal cells o...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1963
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.19.1.139